Co-expressed microRNAs associated with elevated psychometabolic risk phenotype in women during midlife - Takeaways - MDSpire

Co-expressed microRNAs associated with elevated psychometabolic risk phenotype in women during midlife

  • By

  • Kayla D. Longoria

  • Benjamin M. Stroebel

  • Meghana Gadgil

  • Nicole Perez

  • Kimberly A. Lewis

  • Sandra Weiss

  • Elena Flowers

  • June 23, 2026

  • 0 min

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  • 1

    The study identifies multimorbid risk profiles of depression and type 2 diabetes in midlife women aged 40-64 years.

  • 2

    A high-risk profile was characterized by younger age, higher adiposity, glycemic biomarkers, and depression symptom burden.

  • 3

    MicroRNAs miR-320a and miR-320c were associated with increased odds of high-risk profile assignment.

  • 4

    A co-expression cluster of miRs from the miR-320 family was significantly linked to high-risk profile assignment.

  • 5

    Black race demonstrated at least threefold higher odds of high-risk profile assignment compared to other groups.

Original Source(s)

Co-expressed microRNAs associated with elevated psychometabolic risk phenotype in women during midlife

  • by Kayla D. Longoria, Benjamin M. Stroebel, Meghana Gadgil, Nicole Perez, Kimberly A. Lewis, Sandra Weiss, Elena Flowers

  • June 23, 2026

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