Evaluation of Cellular Immune Responses After mRNA-1273 Vaccination in Children 6 Months to 11 Years of Age - Takeaways - MDSpire

Evaluation of Cellular Immune Responses After mRNA-1273 Vaccination in Children 6 Months to 11 Years of Age

  • By

  • Christina A Rostad

  • James D Campbell

  • Grant C Paulsen

  • Sabine Schnyder Ghamloush

  • Wenqin Xu

  • Lingyi Zheng

  • M Juliana McElrath

  • Stephen C De Rosa

  • Bethany Girard

  • Rituparna Das

  • Evan J Anderson

  • C Buddy Creech

  • on behalf of the KidCOVE CMI Study Group

  • March 22, 2025

  • 0 min

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  • 1

    The study assessed T-cell immune responses in children aged 6 months to 11 years following mRNA-1273 vaccination.

  • 2

    mRNA-1273 induced robust Th1-biased CD4+ T-cell responses detectable for at least 6 months post-vaccination.

  • 3

    CD8+ T-cell responses were less frequent in children under 5 years and undetectable in those under 2 years.

  • 4

    Higher frequencies of S-protein-specific polyfunctional CD4+ T cells were observed at day 43 compared to placebo.

  • 5

    Correlation between Th1 CD4+ responses and neutralizing antibodies was noted across all age groups after vaccination.

Original Source(s)

Evaluation of Cellular Immune Responses After mRNA-1273 Vaccination in Children 6 Months to 11 Years of Age

  • by Christina A Rostad, James D Campbell, Grant C Paulsen, Sabine Schnyder Ghamloush, Wenqin Xu, Lingyi Zheng, M Juliana McElrath, Stephen C De Rosa, Bethany Girard, Rituparna Das, Evan J Anderson, C Buddy Creech, on behalf of the KidCOVE CMI Study Group

  • March 22, 2025

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