Lifestyle intervention before and during fertility treatment in women with obesity or with overweight and PCOS—a RCT - Takeaways - MDSpire
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Preconception and Ongoing Lifestyle Modifications in Overweight or Obese Women with PCOS Undergoing Fertility Treatment—A Randomized Controlled Trial

  • By

  • Matea Belan

  • Madélie Giguère-Johnson

  • Belina Carranza-Mamane

  • Marie-Hélène Pesant

  • Youssef AinMelk

  • Marie-France Langlois

  • Hélène Lavoie

  • Ellen M Greenblatt

  • Sheila Laredo

  • Margaret Sagle

  • Guy Waddell

  • Farrah Jean-Denis

  • Jean-Patrice Baillargeon

  • December 16, 2025

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  • 1

    The study evaluated a lifestyle intervention's effectiveness on fertility outcomes in overweight or obese women with PCOS.

  • 2

    Participants included 127 women aged 18 to 40 years with infertility and obesity, randomized into intervention and control groups.

  • 3

    The intervention group lost significantly more weight and waist circumference compared to the control group after 6 months.

  • 4

    Live-birth rates were 44.4% in the intervention group versus 35.9% in the control group, but the difference was not statistically significant.

  • 5

    The lifestyle intervention significantly increased natural pregnancy rates, potentially reducing the need for assisted reproduction.

Original Source(s)

Lifestyle intervention before and during fertility treatment in women with obesity or with overweight and PCOS—a RCT

  • by Matea Belan, Madélie Giguère-Johnson, Belina Carranza-Mamane, Marie-Hélène Pesant, Youssef AinMelk, Marie-France Langlois, Hélène Lavoie, Ellen M Greenblatt, Sheila Laredo, Margaret Sagle, Guy Waddell, Farrah Jean-Denis, Jean-Patrice Baillargeon

  • December 16, 2025

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