Feasibility of opportunistic bone health assessment using low-dose CT trabecular attenuation and 18F-NaF uptake from PET/CT in prostate cancer - Takeaways - MDSpire

Evaluation of the Viability of Opportunistic Bone Health Evaluation Utilizing Low-Dose CT Trabecular Attenuation and 18F-NaF PET/CT Uptake in Prostate Cancer Patients

  • By

  • Cailing Liu

  • Fenghua Liang

  • Zuguo Li

  • Zhenzhen Wang

  • Wei Fu

  • Xingyu Mu

  • July 20, 2026

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  • 1

    The study evaluated the feasibility of using 18F-NaF PET/CT for opportunistic bone health assessment in prostate cancer patients.

  • 2

    A total of 105 men with prostate cancer without bone metastasis underwent 18F-NaF PET/CT for this evaluation.

  • 3

    PET/CT-derived trabecular attenuation showed strong agreement with stand-alone diagnostic CT, indicating its potential for bone health assessment.

  • 4

    The study found that metabolic-structural discordance was present in some patients, highlighting the complexity of bone health evaluation.

  • 5

    Findings suggest that 18F-NaF PET/CT could refine gray-zone stratification in prostate cancer, but require further validation.

Original Source(s)

Feasibility of opportunistic bone health assessment using low-dose CT trabecular attenuation and 18F-NaF uptake from PET/CT in prostate cancer

  • by Cailing Liu, Fenghua Liang, Zuguo Li, Zhenzhen Wang, Wei Fu, Xingyu Mu

  • July 20, 2026

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