Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection - Takeaways - MDSpire

Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection

  • By

  • Anucha Preechanukul

  • Aljawharah Alrubayyi

  • Bo Sun

  • Edward Arbe-Barnes

  • Jonida Kokici

  • Frances Gorou

  • Sarun Prasitdumrong

  • Kelly A S da Costa

  • Natasha Fisher-Pearson

  • Noshin Hussain

  • Stephanie Kucykowicz

  • Indrajit Ghosh

  • Fiona Burns

  • Sabine Kinloch

  • Pedro Simoes

  • Sanjay Bhagani

  • Patrick T F Kennedy

  • Mala K Maini

  • Rachael Bashford-Rogers

  • Upkar S Gill

  • Dimitra Peppa

  • July 1, 2026

  • 0 min

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  • 1

    Chronic HBV infection leads to CD8+ T cell dysfunction, crucial for antiviral responses, particularly in HBV/HIV co-infected individuals.

  • 2

    Co-infected individuals on antiviral therapy show a higher prevalence of precursor exhausted CD8+ T cells, enhancing antiviral responses compared to HBV mono-infection.

  • 3

    The study reveals a paradoxical increase in terminally exhausted CD8+ T cells in HBV mono-infection, highlighting differences in T cell profiles.

  • 4

    Findings suggest tailored immunotherapies could revitalize antiviral responses in HBV/HIV co-infected individuals, emphasizing early intervention.

  • 5

    Identifying HBV/HIV co-infected individuals as candidates for checkpoint-based immunotherapies may improve clinical management and outcomes.

Original Source(s)

Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection

  • by Anucha Preechanukul, Aljawharah Alrubayyi, Bo Sun, Edward Arbe-Barnes, Jonida Kokici, Frances Gorou, Sarun Prasitdumrong, Kelly A S da Costa, Natasha Fisher-Pearson, Noshin Hussain, Stephanie Kucykowicz, Indrajit Ghosh, Fiona Burns, Sabine Kinloch, Pedro Simoes, Sanjay Bhagani, Patrick T F Kennedy, Mala K Maini, Rachael Bashford-Rogers, Upkar S Gill, Dimitra Peppa

  • July 1, 2026

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