Sex-dependent transcriptional and epigenetic regulation of neutrophil inflammatory programs in COPD - Takeaways - MDSpire

Sex-dependent transcriptional and epigenetic regulation of neutrophil inflammatory programs in COPD

  • By

  • Barbara Mariotti

  • Sara Gasperini

  • Chiara Bracaglia

  • Carlo Frigenti

  • Giulia Sartori

  • Claudia di Chiara

  • Francesca Sangiovanni

  • Ernesto Crisafulli

  • Flavia Bazzoni

  • May 28, 2026

  • 0 min

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  • 1

    Chronic obstructive pulmonary disease (COPD).

  • 2

    Neutrophils.

  • 3

    Biological sex shapes immune regulatory mechanisms and responses in COPD, leading to differences in disease susceptibility and progression.

  • 4

    Robust enrichment of interferon signaling, cytokine-mediated pathways, and inflammatory networks.

  • 5

    Transcriptional programs related to autophagy and vesicle-mediated processes.

Original Source(s)

Sex-dependent transcriptional and epigenetic regulation of neutrophil inflammatory programs in COPD

  • by Barbara Mariotti, Sara Gasperini, Chiara Bracaglia, Carlo Frigenti, Giulia Sartori, Claudia di Chiara, Francesca Sangiovanni, Ernesto Crisafulli, Flavia Bazzoni

  • May 28, 2026

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