Occult cervical microinvasive squamous cell carcinoma with superficial endometrial spread mimicking high-grade squamous intraepithelial lesion in a postmenopausal woman: a case report - Takeaways - MDSpire
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Microinvasive Squamous Cell Carcinoma of the Cervix with Endometrial Involvement Misidentified as High-Grade Squamous Intraepithelial Lesion in a Postmenopausal Patient: A Case Study

  • By

  • Yuying Chen

  • Xi Zhao

  • Gege Wang

  • Ziwei Liu

  • Guangchao Sun

  • Yan Jia

  • July 16, 2026

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  • 1

    A 56-year-old postmenopausal woman was misdiagnosed with high-grade squamous intraepithelial lesion during conization.

  • 2

    Final pathology revealed microinvasive squamous cell carcinoma with superficial endometrial spread, not identified in initial assessments.

  • 3

    Immunohistochemistry confirmed the cervical origin of the neoplasm, distinguishing it from primary endometrial disease.

  • 4

    Cervical atrophy in postmenopausal women may compromise diagnostic accuracy of colposcopy and conization.

  • 5

    The case emphasizes the need for careful evaluation of cervical lesions in postmenopausal women to avoid underestimating invasive disease.

Original Source(s)

Occult cervical microinvasive squamous cell carcinoma with superficial endometrial spread mimicking high-grade squamous intraepithelial lesion in a postmenopausal woman: a case report

  • by Yuying Chen, Xi Zhao, Gege Wang, Ziwei Liu, Guangchao Sun, Yan Jia

  • July 16, 2026

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