Ultrasound-guided preseptal hydrodissection with 5% dextrose in water for persistent botulinum toxin-associated ptosis: a technical protocol - Takeaways - MDSpire

Ultrasound-guided preseptal hydrodissection with 5% dextrose in water for persistent botulinum toxin-associated ptosis: a technical protocol

  • By

  • King Hei Stanley Lam

  • Yonghyun Yoon

  • Jihyo Hwang

  • Hyemi Yu

  • Seungbeom Kim

  • Daniel Chiung-Jui Su

  • May 18, 2026

  • 0 min

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  • 1

    Botulinum toxin type A can cause persistent blepharoptosis in 2%-5% of cases, creating a significant clinical challenge for affected patients.

  • 2

    Current treatments for BoNT-A-induced ptosis are often temporary or invasive, highlighting the need for effective minimally invasive interventions.

  • 3

    The novel ultrasound-guided preseptal hydrodissection technique uses 5% dextrose in water to create a fluid layer for treating persistent ptosis.

  • 4

    In two patients treated with this technique, MRD1 improved significantly, with results maintained for 3–6 months without adverse events.

  • 5

    Further prospective controlled trials are necessary to establish the efficacy and safety of this hydrodissection technique for BoNT-A-associated ptosis.

Original Source(s)

Ultrasound-guided preseptal hydrodissection with 5% dextrose in water for persistent botulinum toxin-associated ptosis: a technical protocol

  • by King Hei Stanley Lam, Yonghyun Yoon, Jihyo Hwang, Hyemi Yu, Seungbeom Kim, Daniel Chiung-Jui Su

  • May 18, 2026

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