The coming of age of the pediatric EBMT criteria - Takeaways - MDSpire

The coming of age of the pediatric EBMT criteria

  • By

  • Selim Corbacioglu

  • November 21, 2020

  • 0 min

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  • 1

    Sinusoidal obstruction syndrome (SOS/VOD) is a serious complication post-hematopoietic stem cell transplantation (HSCT) with specific clinical signs.

  • 2

    The pediatric EBMT (pEBMT) criteria were developed to address limitations in existing diagnostic criteria for SOS/VOD in children.

  • 3

    Refractory thrombocytopenia (TRT) is recognized as a sensitive predictor of SOS/VOD and is now included in the pEBMT criteria.

  • 4

    Early intervention with defibrotide (DF) is crucial for improving outcomes in SOS/VOD, as shown by recent trials.

  • 5

    The pEBMT criteria demonstrated a higher incidence of SOS/VOD but allowed for earlier diagnosis and treatment compared to previous criteria.

Original Source(s)

The coming of age of the pediatric EBMT criteria

  • by Selim Corbacioglu

  • November 21, 2020

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