Evolving Perspectives on Pediatric EBMT Criteria

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Sinusoidal obstruction syndrome (SOS/VOD) is a serious complication post-hematopoietic stem cell transplantation (HSCT) with specific clinical signs.
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The pediatric EBMT (pEBMT) criteria were developed to address limitations in existing diagnostic criteria for SOS/VOD in children.
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Refractory thrombocytopenia (TRT) is recognized as a sensitive predictor of SOS/VOD and is now included in the pEBMT criteria.
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Early intervention with defibrotide (DF) is crucial for improving outcomes in SOS/VOD, as shown by recent trials.
5

The pEBMT criteria demonstrated a higher incidence of SOS/VOD but allowed for earlier diagnosis and treatment compared to previous criteria.

Bone Marrow Transplantation

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