Multidrug-resistant bacterial infections in the liver transplant setting

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The liver is crucial for immune defense and is affected by cirrhosis-associated immune dysfunction, leading to increased bacterial infections.
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Multidrug-resistant organisms (MDRO) infections are a growing public health issue, particularly in liver transplant and hepatology settings.
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MDRO infections account for 20-34% of culture-positive bacterial infections in cirrhosis, with significant geographical variability in prevalence.
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Risk factors for MDRO infections in end-stage liver disease include repeated hospitalizations, prior antibiotic exposure, and invasive procedures.
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Antibiotic overuse and prophylaxis may contribute to MDRO infections, but the relationship remains debated and requires further investigation.

Updates In Surgery

by Alberto Ferrarese, Marco Senzolo, Lolita Sasset, Domenico Bassi, Umberto Cillo, Patrizia Burra
June 25, 2024

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