Comparative predictive value of nine inflammation-derived haematological indices for 28-day mortality in patients with sepsis: a multicentre retrospective cohort study - Takeaways - MDSpire

Comparative predictive value of nine inflammation-derived haematological indices for 28-day mortality in patients with sepsis: a multicentre retrospective cohort study

  • By

  • Kaihuan Zhou

  • Chen Ou

  • Xiaorong Li

  • Zhanhong Tang

  • Juntao Hu

  • June 19, 2026

  • 0 min

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  • 1

    This study evaluated nine inflammation-derived hematological indices for their prognostic value in 28-day mortality among sepsis patients.

  • 2

    The development cohort included 26,512 sepsis patients, with 2,669 deaths within 28 days, while the external validation cohort had 850 patients.

  • 3

    All nine indices were significantly associated with 28-day mortality in the development cohort, with the neutrophil-to-lymphocyte ratio showing the highest area under the curve.

  • 4

    In the external validation cohort, none of the indices remained significantly associated with 28-day mortality after full adjustment.

  • 5

    The study concluded that these indices may serve as supplementary markers alongside conventional severity scores rather than independent mortality predictors.

Original Source(s)

Comparative predictive value of nine inflammation-derived haematological indices for 28-day mortality in patients with sepsis: a multicentre retrospective cohort study

  • by Kaihuan Zhou, Chen Ou, Xiaorong Li, Zhanhong Tang, Juntao Hu

  • June 19, 2026

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