Growth Hormone Withdrawal in Mid-Puberty: No Impact on Near Adult Height in Adolescents With Transient Idiopathic GHD - Takeaways - MDSpire

Growth Hormone Withdrawal in Mid-Puberty: No Impact on Near Adult Height in Adolescents With Transient Idiopathic GHD

  • By

  • Joeri Vliegenthart

  • Jan M Wit

  • Boudewijn Bakker

  • Annemieke M Boot

  • Christiaan de Bruin

  • Martijn J J Finken

  • Josine C van der Heyden

  • Anita C S Hokken-Koelega

  • Hetty J van der Kamp

  • Edgar G van Mil

  • Theo C J Sas

  • Dina A Schott

  • Petra van Setten

  • Saartje Straetemans

  • Vera van Tellingen

  • Robbert N H Touwslager

  • A S Paul van Trotsenburg

  • Paul G Voorhoeve

  • Edmond H H M Rings

  • Erica L T van den Akker

  • Danielle C M van der Kaay

  • November 15, 2025

  • 0 min

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  • 1

    The study assessed the impact of discontinuing rhGH treatment at mid-puberty on final height in adolescents with transient IIGHD.

  • 2

    A total of 127 adolescents participated, with 44 continuing rhGH and 83 discontinuing treatment after retesting showed GH sufficiency.

  • 3

    Mean NAH-SDS was similar between the GHcont and GHstop groups, indicating no significant height difference due to treatment discontinuation.

  • 4

    Total pubertal growth was comparable between both groups, suggesting that mid-puberty rhGH withdrawal does not adversely affect growth.

  • 5

    The findings support reducing rhGH treatment duration, potentially lowering patient burden and healthcare costs without compromising height.

Original Source(s)

Growth Hormone Withdrawal in Mid-Puberty: No Impact on Near Adult Height in Adolescents With Transient Idiopathic GHD

  • by Joeri Vliegenthart, Jan M Wit, Boudewijn Bakker, Annemieke M Boot, Christiaan de Bruin, Martijn J J Finken, Josine C van der Heyden, Anita C S Hokken-Koelega, Hetty J van der Kamp, Edgar G van Mil, Theo C J Sas, Dina A Schott, Petra van Setten, Saartje Straetemans, Vera van Tellingen, Robbert N H Touwslager, A S Paul van Trotsenburg, Paul G Voorhoeve, Edmond H H M Rings, Erica L T van den Akker, Danielle C M van der Kaay

  • November 15, 2025

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