Persistent meningeal enhancement on MRI in an infant with culture-negative bacterial meningitis: a case report and systematic review of the literature (2014–2025) - Takeaways - MDSpire

Persistent meningeal enhancement on MRI in an infant with culture-negative bacterial meningitis: a case report and systematic review of the literature (2014–2025)

  • By

  • Qunyan Su

  • Yiping Shao

  • Jingjing Jin

  • Yinghua Yan

  • Jiangyin Sheng

  • Anqian Tao

  • Guiying Ruan

  • Licheng Cui

  • Yandan Yin

  • July 14, 2026

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  • 1

    A 70-day-old infant with culture-negative bacterial meningitis exhibited 5-month persistent meningeal enhancement post-treatment without clinical symptoms.

  • 2

    The infant's clinical recovery included normalization of cerebrospinal fluid parameters and systemic inflammatory markers after antimicrobial therapy.

  • 3

    Persistent meningeal enhancement may be misinterpreted as infection recurrence, leading to unnecessary treatments and procedures.

  • 4

    The study systematically reviewed 17 studies on meningeal enhancement in infantile bacterial meningitis from 2014 to 2025.

  • 5

    Long-term follow-up is essential to confirm the benign nature of persistent meningeal enhancement in culture-negative cases.

Original Source(s)

Persistent meningeal enhancement on MRI in an infant with culture-negative bacterial meningitis: a case report and systematic review of the literature (2014–2025)

  • by Qunyan Su, Yiping Shao, Jingjing Jin, Yinghua Yan, Jiangyin Sheng, Anqian Tao, Guiying Ruan, Licheng Cui, Yandan Yin

  • July 14, 2026

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