Several motor proteins control anterograde axonal transport of TDP-43

1

TDP-43 is predominantly nuclear under physiological conditions but also supports mRNA trafficking and local translation in axons and dendrites.
2

TDP-43 pathology includes nuclear depletion and cytoplasmic accumulation in approximately 97% of sporadic ALS cases.
3

In H9-derived neurons, live-cell imaging showed processive anterograde TDP-43 movement with kinetics comparable to vesicular cargoes.
4

Biochemical assays and proximity ligation analyses found TDP-43 interactions with anterograde and retrograde transport machinery.
5

TDP-43 interacted with kinesin-1 isoforms KIF5A, KIF5B, and KIF5C via KLC1, and with kinesin-3 family member KIF1A.

Acta Neuropathologica

by Monica Feole, Victorio M. Pozo Devoto, Neda Dragišić, Maria Čarna, Katja Klosterman, Clara Limbaek-Stokin, Giancarlo Forte, Kenneth L. Moya, Richard A. Smith, Clive N. Svendsen, Gorazd B. Stokin
October 9, 2026

1