Gout and allopurinol adherence in newly diagnosed patients and the risk of fractures: a nationwide cohort study - Takeaways - MDSpire

Adherence to Allopurinol in Newly Diagnosed Gout Patients and Its Association with Fracture Risk: A Nationwide Cohort Analysis

  • By

  • Jang Ho Doo

  • Jiwon Yu

  • Sun Jae Park

  • Sang woo Park

  • Jina Chung

  • Ju Hyun Kang

  • Young Jun Park

  • Hyun-Young Shin

  • Changho Han

  • Byeongzu Ghang

  • Sang Min Park

  • July 17, 2026

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  • 1

    Gout is characterized by recurrent acute monoarthritis due to monosodium urate crystal deposition and may progress to chronic arthritis with tophi.

  • 2

    The incidence and prevalence of gout have increased significantly in Korea from 2007 to 2015, reflecting a growing public health concern.

  • 3

    The relationship between gout, serum uric acid levels, and fracture risk remains debated, with studies showing conflicting evidence on their associations.

  • 4

    This study analyzed a cohort of 4,107 gout patients on allopurinol to evaluate the impact of medication adherence on fracture risk.

  • 5

    The medication possession ratio (MPR) was used to assess adherence to allopurinol over a 24-month period following gout diagnosis.

Original Source(s)

Gout and allopurinol adherence in newly diagnosed patients and the risk of fractures: a nationwide cohort study

  • by Jang Ho Doo, Jiwon Yu, Sun Jae Park, Sang woo Park, Jina Chung, Ju Hyun Kang, Young Jun Park, Hyun-Young Shin, Changho Han, Byeongzu Ghang, Sang Min Park

  • July 17, 2026

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