Gene-Environment Interactions in Inflammatory Bowel Disease: A Systematic Review of Human Epidemiologic Studies - Takeaways - MDSpire

Gene-Environment Interactions in Inflammatory Bowel Disease: A Systematic Review of Human Epidemiologic Studies

  • By

  • Jingjing Bai

  • Dianne Gelien Bouwknegt

  • Rinse Karel Weersma

  • Gerard Dijkstra

  • Kimberley Wilhelmina Johanna van der Sloot

  • Eleonora Anna Margaretha Festen

  • June 4, 2025

  • 0 min

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  • 1

    This systematic review summarizes evidence of gene-environment interactions in inflammatory bowel disease (IBD) from 39 eligible studies.

  • 2

    NOD2-smoking interactions were frequently studied, showing variant-specific effects on Crohn's disease risk.

  • 3

    Gene-diet interactions were identified, linking various nutritional factors with specific genetic variants associated with IBD.

  • 4

    Environmental factors influencing IBD risk vary among individuals based on their genetic backgrounds.

  • 5

    Further research is needed to explore genome-wide environment interactions and develop personalized lifestyle recommendations.

Original Source(s)

Gene-Environment Interactions in Inflammatory Bowel Disease: A Systematic Review of Human Epidemiologic Studies

  • by Jingjing Bai, Dianne Gelien Bouwknegt, Rinse Karel Weersma, Gerard Dijkstra, Kimberley Wilhelmina Johanna van der Sloot, Eleonora Anna Margaretha Festen

  • June 4, 2025

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