Rates of Leucovorin Prescriptions for Children With Autism - Takeaways - MDSpire

Rates of Leucovorin Prescriptions for Children With Autism

  • By

  • Joshua M. Rothman

  • Brian Kwan

  • Christopher A. Longhurst

  • Anupam B. Jena

  • May 18, 2026

  • 0 min

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  • 1

    Leucovorin prescriptions for children with autism spectrum disorder (ASD) rose sharply following a White House announcement in September 2025.

  • 2

    The study analyzed over 11 million outpatient encounters, revealing a 24-fold increase in leucovorin prescriptions from early 2023 to late 2025.

  • 3

    Increased media attention and public endorsements may have contributed to the rising trend in leucovorin use among pediatric ASD patients.

  • 4

    Despite rising prescriptions, no large-scale studies confirm the safety and efficacy of leucovorin for treating ASD.

  • 5

    The FDA has not approved leucovorin for ASD, highlighting the need for ongoing monitoring of its prescribing trends.

Original Source(s)

Rates of Leucovorin Prescriptions for Children With Autism

  • by Joshua M. Rothman, Brian Kwan, Christopher A. Longhurst, Anupam B. Jena

  • May 18, 2026

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