Identification of MTMR2 as an AML-associated candidate biomarker derived from lipid metabolism–related transcriptomic analysis - Takeaways - MDSpire

Identification of MTMR2 as an AML-associated candidate biomarker derived from lipid metabolism–related transcriptomic analysis

  • By

  • Chenchen Liu

  • Yueyuan Pan

  • Minggui Chen

  • Songyu Li

  • Chong Zhang

  • May 29, 2026

  • 0 min

Share

  • 1

    MTMR2 is identified as a potential biomarker linked to lipid metabolism in acute myeloid leukemia (AML) through comprehensive transcriptomic analysis.

  • 2

    Lipid metabolism-related pathways are significantly altered in AML, suggesting their role in disease progression and potential for biomarker discovery.

  • 3

    High MTMR2 expression correlates with poorer overall survival in AML patients, indicating its prognostic relevance.

  • 4

    MTMR2 shows good diagnostic performance and is upregulated in AML across independent datasets, validated by RT-qPCR.

  • 5

    Exploratory analysis reveals altered lipid-related parameters in AML patients, including lower ApoA1 and LDL-C levels and higher TG levels.

Original Source(s)

Identification of MTMR2 as an AML-associated candidate biomarker derived from lipid metabolism–related transcriptomic analysis

  • by Chenchen Liu, Yueyuan Pan, Minggui Chen, Songyu Li, Chong Zhang

  • May 29, 2026

Related Content

A pilot study combining primary busulfan-based haploidentical stem cell transplantation with GD2 antibody to treat high-risk neuroblastoma

A review of epidermal growth factor receptor ligands in glucose homeostasis

Diffuse large B-cell lymphoma presenting as a scalp tumor with skull destruction and neurological symptoms: a case report