The lactate–lactylation axis in tumor radioresistance: metabolic, epigenetic, and immune mechanisms with emerging links to RNA regulation - Takeaways - MDSpire

The lactate–lactylation axis in tumor radioresistance: metabolic, epigenetic, and immune mechanisms with emerging links to RNA regulation

  • By

  • Yuxiang Zhang

  • Jiaqi Zhang

  • Yun Cao

  • June 24, 2026

  • 0 min

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  • 1

    Radiotherapy is a key treatment for solid tumors, but its effectiveness is often compromised by tumor radioresistance.

  • 2

    Lactate metabolism and protein lactylation are emerging as significant regulators of tumor adaptation to irradiation.

  • 3

    Lactate influences DNA damage repair, redox buffering, and clonogenic survival in irradiated tumor models.

  • 4

    Histone lysine lactylation connects metabolism and epigenetic control, potentially contributing to tumor radioresistance.

  • 5

    Therapeutic strategies targeting the lactate-lactylation axis include MCT and LDH inhibitors, oxidative phosphorylation blockade, and lactate-depleting nanoplatforms.

Original Source(s)

The lactate–lactylation axis in tumor radioresistance: metabolic, epigenetic, and immune mechanisms with emerging links to RNA regulation

  • by Yuxiang Zhang, Jiaqi Zhang, Yun Cao

  • June 24, 2026

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