Case Report: Reopening the anabolic window — romosozumab added to ongoing denosumab for severe osteoporosis in two kidney transplant recipients - Takeaways - MDSpire
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Case Study: Reactivating the Anabolic Window — The Use of Romosozumab Alongside Denosumab in Two Female Patients with Severe Osteoporosis Post-Kidney Transplant

  • By

  • Simona Barbuto

  • Paolo Mastromauro

  • Guido Zavatta

  • Daniele Vetrano

  • Anna Mistretta

  • Nicolò Bisceglia

  • Giorgia Comai

  • Uberto Pagotto

  • Gaetano La Manna

  • Giuseppe Cianciolo

  • September 4, 2026

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  • 1

    Kidney transplant recipients are at high risk for osteoporosis and fractures due to mineral and bone metabolism disorders.

  • 2

    Romosozumab was added to denosumab therapy in two women with severe osteoporosis, leading to increased bone mineral density.

  • 3

    Both patients showed early increases in bone-formation markers and significant improvements in lumbar spine bone mineral density.

  • 4

    Stable serum calcium, parathyroid hormone, and allograft function were maintained throughout the treatment period.

  • 5

    The combination therapy did not lead to new vertebral fractures or clinically significant hypocalcemia in either patient.

Original Source(s)

Case Report: Reopening the anabolic window — romosozumab added to ongoing denosumab for severe osteoporosis in two kidney transplant recipients

  • by Simona Barbuto, Paolo Mastromauro, Guido Zavatta, Daniele Vetrano, Anna Mistretta, Nicolò Bisceglia, Giorgia Comai, Uberto Pagotto, Gaetano La Manna, Giuseppe Cianciolo

  • September 4, 2026

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