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1
Metabolomic ageing varies across mental disorders, with substance use, psychotic, affective, and neurotic disorders linked to older metabolite-predicted ages.
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2
Obsessive-compulsive and eating disorders are associated with younger metabolomic ages compared to chronological age.
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3
Associations between metabolomic ageing and mental disorders differ by sex and are generally stronger in individuals under 65 years.
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4
Higher genetic liability to depression, autism, and ADHD predicts older metabolomic ages, while psychosis and tobacco use disorder predict younger ages.
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5
Biological age in mental disorders should not be assumed to exceed chronological age uniformly, highlighting the need for sex and age-specific approaches.
