Maternal factors associate with microbiota-derived extracellular vesicle profiles in pregnancy: a clinical cohort study - Takeaways - MDSpire
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Influence of Maternal Characteristics on Profiles of Microbiota-Derived Extracellular Vesicles During Pregnancy: Findings from a Clinical Cohort Study

  • By

  • Jenni Turunen

  • Kaisu Kyrö

  • Janica Virta

  • Marko Suokas

  • Jenni Hekkala

  • Sonja Karikka

  • Anna Kaisanlahti

  • Justus Reunanen

  • Niko Paalanne

  • Mysore V. Tejesvi

  • Terhi Ruuska-Loewald

  • May 28, 2026

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  • 1

    Microbiota-derived extracellular vesicles (EVs) are lipid-bilayer nanoparticles secreted by bacteria, interacting with the host in various ways.

  • 2

    The study investigated how maternal factors influence the secretion of microbiota-derived EVs into the amniotic fluid and feces of pregnant women.

  • 3

    A clinical cohort study of 508 mother-infant dyads collected fecal and amniotic fluid samples to analyze microbiota-derived EVs.

  • 4

    The study utilized a specific protocol for isolating microbiota-derived EVs with minimal human EV presence, ensuring accurate characterization.

  • 5

    Amniotic fluid samples were processed to isolate microbiota-derived EVs, confirming the presence of bacterial proteins in the fluid.

Original Source(s)

Maternal factors associate with microbiota-derived extracellular vesicle profiles in pregnancy: a clinical cohort study

  • by Jenni Turunen, Kaisu Kyrö, Janica Virta, Marko Suokas, Jenni Hekkala, Sonja Karikka, Anna Kaisanlahti, Justus Reunanen, Niko Paalanne, Mysore V. Tejesvi, Terhi Ruuska-Loewald

  • May 28, 2026

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