MAFLD is associated with lower bone mineral density in patients with type 2 diabetes: an exploratory cross-sectional analysis of a potential indirect association with HOMA-IR - Takeaways - MDSpire

MAFLD is associated with lower bone mineral density in patients with type 2 diabetes: an exploratory cross-sectional analysis of a potential indirect association with HOMA-IR

  • By

  • Lu Lin

  • Yanqian Zhuang

  • Rongkun Xu

  • Wencheng Yi

  • Pin Chen

  • Wenqing Wang

  • May 22, 2026

  • 0 min

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  • 1

    MAFLD is associated with significantly lower bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).

  • 2

    Patients with MAFLD had a higher prevalence of osteopenia/osteoporosis compared to those without MAFLD.

  • 3

    Insulin resistance, indicated by HOMA-IR, partially mediates the relationship between MAFLD and reduced BMD.

  • 4

    The study utilized a cross-sectional design, limiting the ability to establish causality between MAFLD and BMD.

  • 5

    FIB-4 was not independently associated with BMD in the context of this study.

Original Source(s)

MAFLD is associated with lower bone mineral density in patients with type 2 diabetes: an exploratory cross-sectional analysis of a potential indirect association with HOMA-IR

  • by Lu Lin, Yanqian Zhuang, Rongkun Xu, Wencheng Yi, Pin Chen, Wenqing Wang

  • May 22, 2026

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