Glioblastoma, IDH-wildtype, with a novel MEF2D-NTRK1 gene fusion: a case report - Takeaways - MDSpire

Glioblastoma, IDH-wildtype, with a novel MEF2D-NTRK1 gene fusion: a case report

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A 56-year-old woman was diagnosed with IDH-wildtype glioblastoma featuring a rare MEF2D-NTRK1 gene fusion.
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The patient underwent subtotal resection of a large right parietal mass, followed by chemoradiation with temozolomide.
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Next-generation sequencing revealed an unmethylated MGMT promoter and a TERT promoter mutation in the tumor.
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After initial treatment, the patient progressed and was started on repotrectinib and bevacizumab targeting the gene fusion.
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The case highlights the importance of genomic profiling in guiding treatment decisions for rare glioblastoma variants.