Midsystolic Doppler Signal Void Identifies Midapical Obstruction in Hypertrophic Cardiomyopathy - Takeaways - MDSpire
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Detection of Midapical Obstruction in Hypertrophic Cardiomyopathy via Midsystolic Doppler Signal Absence

  • By

  • Zhenzhen Wang

  • Wei Liu

  • Wei Li

  • Wensheng Tao

  • Jiayi Chen

  • Wenxiu Ye

  • Zhiqiang Dong

  • Shuwei Wang

  • Bing Zhou

  • Meijuan Yan

  • Yong Cui

  • July 2, 2026

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  • 1

    Hypertrophic cardiomyopathy (HCM) includes midapical obstruction, a distinct phenotype associated with adverse structural remodeling and potentially elevated clinical risk.

  • 2

    Standardized echocardiographic criteria for identifying midapical obstruction in HCM remain limited.

  • 3

    A midsystolic Doppler signal void reflects systolic midapical cavity obliteration with abrupt attenuation or near-complete absence of forward flow.

  • 4

    The study evaluated 606 consecutive patients with HCM to determine the prevalence and clinical correlates of midsystolic Doppler signal void.

  • 5

    Midsystolic Doppler signal void may identify a distinct midapical obstructive phenotype not fully captured by conventional Doppler gradient measurements alone.

Original Source(s)

Midsystolic Doppler Signal Void Identifies Midapical Obstruction in Hypertrophic Cardiomyopathy

  • by Zhenzhen Wang, Wei Liu, Wei Li, Wensheng Tao, Jiayi Chen, Wenxiu Ye, Zhiqiang Dong, Shuwei Wang, Bing Zhou, Meijuan Yan, Yong Cui

  • July 2, 2026

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