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Azithromycin uptake may reduce postcesarean infections

Trial evidence translated into wider clinical use as postpartum infection rates declined in US practice.

  • By

  • Andrea Surnit

  • September 30, 2026

  • 4 min

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  • 1

    Adjunctive azithromycin use during unscheduled cesarean deliveries in the U.S. increased from 2% to 40% after the C/SOAP trial publication.

  • 2

    Postpartum infection rates following cesarean deliveries decreased from 9% to 8%, while rates for vaginal deliveries increased from 2% to 3%.

  • 3

    The study found a 2-percentage-point reduction in postpartum infections, equating to a 20% relative decrease after azithromycin use.

  • 4

    Fewer than 50% of cesarean delivery patients received azithromycin post-publication, indicating incomplete adoption of the treatment.

  • 5

    The study faced limitations, including inability to distinguish between scheduled and unscheduled cesarean deliveries and potential residual confounding.

Original Source(s)

Azithromycin uptake may reduce postcesarean infections

  • by Andrea Surnit

  • September 30, 2026

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