Radiotherapy plus immunotherapy with or without chemotherapy improves survival in elderly esophageal squamous cell carcinoma: a real-world comorbidity-stratified study - Takeaways - MDSpire

Radiotherapy plus immunotherapy with or without chemotherapy improves survival in elderly esophageal squamous cell carcinoma: a real-world comorbidity-stratified study

  • By

  • Hong jian Ren

  • Qi lin Ren

  • Zhi juan Zhang

  • Jun jie Lei

  • Ning Xu

  • May 4, 2026

  • 0 min

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  • 1

    The study investigates the efficacy of radiotherapy combined with immunotherapy in elderly patients with esophageal squamous cell carcinoma.

  • 2

    Results indicate that the RIT ± CT regimen significantly reduces mortality risk compared to radiotherapy alone in older patients.

  • 3

    Patients with medium CIRS-G scores showed the most substantial overall survival benefit from the multimodal treatment strategy.

  • 4

    Grade ≥3 treatment-related adverse events were highest in the RIT ± CT group, but no treatment-related deaths occurred.

  • 5

    The findings suggest that immunotherapy integration may improve survival in elderly ESCC patients, warranting further validation in larger studies.

Original Source(s)

Radiotherapy plus immunotherapy with or without chemotherapy improves survival in elderly esophageal squamous cell carcinoma: a real-world comorbidity-stratified study

  • by Hong jian Ren, Qi lin Ren, Zhi juan Zhang, Jun jie Lei, Ning Xu

  • May 4, 2026

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