Longitudinal trajectories of urinary albumin-to-creatinine ratio and risk of proteinuria among Chinese patients with type 2 diabetes: a single−center retrospective cohort study - Takeaways - MDSpire

Longitudinal trajectories of urinary albumin-to-creatinine ratio and risk of proteinuria among Chinese patients with type 2 diabetes: a single−center retrospective cohort study

  • By

  • Qian Chen

  • Tieqiao Wang

  • Xiaoqing Tian

  • Qiankai Jin

  • Li Li

  • Yushan Mao

  • Guoqing Huang

  • June 2, 2026

  • 0 min

Share

  • 1

    The study analyzed UACR trajectories in 3,101 Chinese T2DM patients with baseline UACR <30 mg/g from March 2018 to October 2024.

  • 2

    Three distinct UACR trajectories were identified: low-normal, mid-range normal, and rising with fluctuation.

  • 3

    Key features associated with UACR trajectories included baseline UACR, sex, height, Hb, HCT, BMI, waist circumference, RBC, FCP, SCR, and FINS.

  • 4

    Multivariable Cox regression indicated significantly increased proteinuria risk in mid-range normal and rising with fluctuation groups.

  • 5

    The findings suggest that trajectory-informed classification may enhance early-stage diabetic kidney disease screening in T2DM patients.

Original Source(s)

Longitudinal trajectories of urinary albumin-to-creatinine ratio and risk of proteinuria among Chinese patients with type 2 diabetes: a single−center retrospective cohort study

  • by Qian Chen, Tieqiao Wang, Xiaoqing Tian, Qiankai Jin, Li Li, Yushan Mao, Guoqing Huang

  • June 2, 2026

Related Content

Editorial: Addressing the Challenges of Diabetes Complications and Exploring Innovative Approaches

Utilizing Machine Learning to Identify Risk Factors for Diabetic Microvascular Complications and Develop a Predictive Model with Gradient Boosting Decision Trees