Autoantibodies to Joint-Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals - Takeaways - MDSpire

Association of Autoantibodies to Joint-Related Peptides with the Development of Rheumatoid Arthritis in Asymptomatic Seronegative Patients

  • By

  • Outi Sareila

  • Linda Johansson

  • Anders Lundquist

  • Monica Leu Agelii

  • Lei Cheng

  • Yibo He

  • Erik Lönnblom

  • Maria Andersson

  • Jan Kihlberg

  • Anders Esberg

  • Inger Gjertsson

  • Rikard Holmdahl

  • Solbritt Rantapää-Dahlqvist

  • May 27, 2026

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  • 1

    Rheumatoid arthritis (RA) onset is preceded by elevated autoantibody levels, necessitating early and accurate diagnostic biomarkers.

  • 2

    Approximately 30% to 40% of early RA patients are negative for traditional biomarkers ACPA and RF, highlighting a diagnostic gap.

  • 3

    Novel autoantibodies against joint-related peptides, termed JointIDs, may serve as predictive markers for RA in presymptomatic individuals.

  • 4

    The study analyzed serum samples from 518 presymptomatic individuals, with a median predating time of 4.7 years before RA symptom onset.

  • 5

    The research aims to identify reliable biomarkers to improve the prediction and diagnosis of RA in at-risk populations.

Original Source(s)

Autoantibodies to Joint-Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

  • by Outi Sareila, Linda Johansson, Anders Lundquist, Monica Leu Agelii, Lei Cheng, Yibo He, Erik Lönnblom, Maria Andersson, Jan Kihlberg, Anders Esberg, Inger Gjertsson, Rikard Holmdahl, Solbritt Rantapää-Dahlqvist

  • May 27, 2026

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