HLA-DRB1*15:01 drives sex- and age-dependent microglial immune phenotypes and neuroimmune signaling - Takeaways - MDSpire

HLA-DRB1*15:01 drives sex- and age-dependent microglial immune phenotypes and neuroimmune signaling

  • By

  • Elsa M. Reyes-Reyes

  • Dhanalakshmi Chinnasamy

  • Michael D. Trial

  • Fernando Fernandez

  • Vincent D. Nguyen

  • Qianying He

  • Angel-Grace Leslie

  • Jessica Begay

  • Jessica Triplett

  • David Bradford

  • Carolina Figueroa

  • Jean P. Wiegand

  • Kathleen E. Rodgers

  • June 16, 2026

  • 0 min

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  • 1

    HLA-DRB1*15:01 is the strongest genetic risk factor for multiple sclerosis, influencing neuroimmune vulnerability and chronic neuroinflammation.

  • 2

    In a study using humanized mice, HLA-DRB1*15:01 expression led to age- and sex-dependent cognitive impairments, particularly in aged females.

  • 3

    HLA-DRB1*15:01 expression resulted in increased microglial immune changes, oxidative stress, and altered astrocyte phenotypes.

  • 4

    The study found selective immune remodeling in HLA mice, with increased accumulation of CD4+ T cells and NK1.1+CD3+ NKT cells, especially in females.

  • 5

    Hippocampal cytokine profiling revealed sex-biased alterations without broad induction of classical inflammatory cytokines in HLA mice.

Original Source(s)

HLA-DRB1*15:01 drives sex- and age-dependent microglial immune phenotypes and neuroimmune signaling

  • by Elsa M. Reyes-Reyes, Dhanalakshmi Chinnasamy, Michael D. Trial, Fernando Fernandez, Vincent D. Nguyen, Qianying He, Angel-Grace Leslie, Jessica Begay, Jessica Triplett, David Bradford, Carolina Figueroa, Jean P. Wiegand, Kathleen E. Rodgers

  • June 16, 2026

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