High-sensitivity C-reactive protein mediates age-related vascular dysfunction: the Rotterdam study - Takeaways - MDSpire

High-sensitivity C-reactive protein mediates age-related vascular dysfunction: the Rotterdam study

  • By

  • Soroush Mohammadi Jouabadi

  • Annique Claringbould

  • A H Jan Danser

  • Bruno H Stricker

  • Maryam Kavousi

  • Anton J M Roks

  • Fariba Ahmadizar

  • June 25, 2025

  • 0 min

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  • 1

    High-sensitivity C-reactive protein (hsCRP) mediates the relationship between aging and vascular dysfunction, particularly in men.

  • 2

    The Rotterdam Study analyzed 7591 participants to assess the role of hsCRP in age-related vascular changes.

  • 3

    Mediation analysis showed hsCRP significantly affects carotid intima-media thickness (cIMT) and pulse wave velocity (PWV).

  • 4

    Mendelian randomization indicated a potential causal link between hsCRP and PWV, but not with cIMT.

  • 5

    Findings suggest anti-inflammatory strategies may complement lipid-lowering approaches to reduce cardiovascular risk.

Original Source(s)

High-sensitivity C-reactive protein mediates age-related vascular dysfunction: the Rotterdam study

  • by Soroush Mohammadi Jouabadi, Annique Claringbould, A H Jan Danser, Bruno H Stricker, Maryam Kavousi, Anton J M Roks, Fariba Ahmadizar

  • June 25, 2025

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