Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria - Takeaways - MDSpire

Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria

  • By

  • Ruth Namazzi

  • Caroline Kazinga

  • Giselle Lima-Cooper

  • Claire Liepmann

  • Michael J Goings

  • Olivia Bednarski

  • Marco Abreu

  • Tae-Hwi Schwantes-An

  • Anthony Batte

  • Robert O Opoka

  • Chandy C John

  • Andrea L Conroy

  • February 18, 2025

  • 0 min

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  • 1

    G6PD deficiency prevalence was 16.7% in hemizygous males and 2.4% in females among children with severe malaria.

  • 2

    G6PD deficiency was associated with 2.56-fold increased odds of acute kidney injury in pediatric severe malaria.

  • 3

    The study adjusted for age, sex, nutritional status, and hemolysis markers when evaluating G6PD deficiency and AKI.

  • 4

    Acute kidney injury is a common complication of severe malaria and predicts mortality in affected children.

  • 5

    The G6PD A− allele is linked to increased AKI risk in children with severe malaria, independent of hemolytic events.

Original Source(s)

Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria

  • by Ruth Namazzi, Caroline Kazinga, Giselle Lima-Cooper, Claire Liepmann, Michael J Goings, Olivia Bednarski, Marco Abreu, Tae-Hwi Schwantes-An, Anthony Batte, Robert O Opoka, Chandy C John, Andrea L Conroy

  • February 18, 2025

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