Structural variation drives enhancer hijacking via 3D genome disruption in ccRCC - Takeaways - MDSpire
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Enhancer Hijacking in Clear Cell Renal Cell Carcinoma is Driven by Structural Variation and Disruption of 3D Genome Architecture

  • By

  • Yu Dong

  • Wenjiao Xia

  • Zitong Yang

  • Liangliang Ren

  • Hongru Wang

  • Yiyang Zhou

  • Qinchen Li

  • Zhi Chen

  • Zhinan Xia

  • Yichun Zheng

  • Feifan Wang

  • Ning He

  • Bing Cheng

  • Dongmei Ma

  • Wei Shao

  • Wei Guo

  • Shuwen Wang

  • Ziqiao Liu

  • Junxiao Shen

  • Yiming Qi

  • Xuke Gong

  • Juan Jin

  • Bo Xie

  • Guixin Zhu

  • Cheng Zhang

  • January 6, 2026

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  • 1

    Clear cell renal cell carcinoma (ccRCC) accounts for 70-80% of renal cell carcinoma cases and is characterized by high heterogeneity and aggressiveness.

  • 2

    Structural variants (SVs) significantly contribute to the genetic variation in ccRCC and can disrupt gene expression and regulatory networks.

  • 3

    Advancements in long-read sequencing technologies enable precise detection of SVs and their impact on 3D genome architecture in ccRCC.

  • 4

    The study identifies a novel enhancer hijacking event that activates the proto-oncogene SEMA5B, revealing new therapeutic targets.

  • 5

    A machine learning-based prognostic model developed from enhancer hijacking events shows robust predictive performance for ccRCC outcomes.

Original Source(s)

Structural variation drives enhancer hijacking via 3D genome disruption in ccRCC

  • by Yu Dong, Wenjiao Xia, Zitong Yang, Liangliang Ren, Hongru Wang, Yiyang Zhou, Qinchen Li, Zhi Chen, Zhinan Xia, Yichun Zheng, Feifan Wang, Ning He, Bing Cheng, Dongmei Ma, Wei Shao, Wei Guo, Shuwen Wang, Ziqiao Liu, Junxiao Shen, Yiming Qi, Xuke Gong, Juan Jin, Bo Xie, Guixin Zhu, Cheng Zhang

  • January 6, 2026

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