Ligature-induced periodontitis in mice potentially accelerates CD4+ T-cell senescence and exacerbates rheumatoid arthritis - Takeaways - MDSpire

Ligature-induced periodontitis in mice potentially accelerates CD4+ T-cell senescence and exacerbates rheumatoid arthritis

  • By

  • Jinfeng Li

  • Terukazu Sanui

  • Miyu Shida

  • Karen Yotsumoto

  • Mwannes Ahmad

  • Ziyu Wang

  • Meng Xiao

  • Chikako Hayashi

  • Takanori Shinjo

  • Takaharu Taketomi

  • Takao Fukuda

  • Fusanori Nishimura

  • May 26, 2026

  • 0 min

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  • 1

    Chronic periodontitis accelerates CD4+ T-cell senescence, characterized by increased PD-1 and CD153 expression in mice.

  • 2

    The study found elevated levels of senescence-associated β-galactosidase and SASP cytokines in CD4+ T cells from periodontitis-affected mice.

  • 3

    RNA-seq analysis revealed significant gene expression changes related to senescence in unstimulated CD4+ T cells from the periodontitis group.

  • 4

    Adoptive transfer of senescent CD4+ T cells from periodontitis mice exacerbated collagen antibody-induced arthritis in recipient mice.

  • 5

    These findings suggest a novel mechanism linking chronic periodontitis to systemic diseases like rheumatoid arthritis through T-cell senescence.

Original Source(s)

Ligature-induced periodontitis in mice potentially accelerates CD4+ T-cell senescence and exacerbates rheumatoid arthritis

  • by Jinfeng Li, Terukazu Sanui, Miyu Shida, Karen Yotsumoto, Mwannes Ahmad, Ziyu Wang, Meng Xiao, Chikako Hayashi, Takanori Shinjo, Takaharu Taketomi, Takao Fukuda, Fusanori Nishimura

  • May 26, 2026

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