Non-coding RNA in osteoarthritis: mechanistic insights and future perspectives - Takeaways - MDSpire
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The Role of Non-coding RNAs in Osteoarthritis: Mechanisms and Future Directions

  • By

  • Manali Jain

  • Anamika Kumari Anuja

  • Soniya Yadav

  • Jasmin Ara

  • Anukool Ojha

  • Chandra Prakash Chaturvedi

  • July 14, 2026

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  • 1

    Non-coding RNAs (ncRNAs) are critical regulators of osteoarthritis (OA) pathogenesis, influencing gene expression at various levels.

  • 2

    MicroRNAs (miRNAs), particularly miR-140-5p, play significant roles in cartilage protection and modulate key biological processes in OA.

  • 3

    Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have limited validation in primary human OA tissues compared to miRNAs.

  • 4

    Circulating ncRNAs show potential as minimally invasive biomarkers for OA, although current studies face methodological challenges.

  • 5

    NcRNA-based therapeutics demonstrate promise in preclinical models of OA, but face challenges in delivery efficiency and clinical translation.

Original Source(s)

Non-coding RNA in osteoarthritis: mechanistic insights and future perspectives

  • by Manali Jain, Anamika Kumari Anuja, Soniya Yadav, Jasmin Ara, Anukool Ojha, Chandra Prakash Chaturvedi

  • July 14, 2026

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