Cerebrospinal fluid glucose-to-lactate ratio (CGLR) as a diagnostic biomarker for postoperative intracranial infections in patients with acute brain injury: a prospective diagnostic accuracy study - Takeaways - MDSpire

Cerebrospinal fluid glucose-to-lactate ratio (CGLR) as a diagnostic biomarker for postoperative intracranial infections in patients with acute brain injury: a prospective diagnostic accuracy study

  • By

  • Weidong Wang

  • Huajun Wang

  • Chengjie Zhou

  • Ye Fu

  • June 10, 2026

  • 0 min

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  • 1

    The study evaluated the cerebrospinal fluid glucose-to-lactate ratio (CGLR) for diagnosing postoperative intracranial infections in acute brain injury patients.

  • 2

    CGLR demonstrated a higher diagnostic performance (AUC = 0.866) compared to conventional biomarkers like CSF glucose and lactate.

  • 3

    CGLR values were consistent across different patient cohorts, including those with subarachnoid hemorrhage, intracranial hemorrhage, and traumatic brain injury.

  • 4

    CGLR is a rapid, cost-effective, and reliable biomarker, unaffected by peripheral glucose fluctuations, for detecting postoperative infections.

  • 5

    The study included 121 patients, with 92 samples analyzed, confirming the utility of CGLR in clinical settings for early infection detection.

Original Source(s)

Cerebrospinal fluid glucose-to-lactate ratio (CGLR) as a diagnostic biomarker for postoperative intracranial infections in patients with acute brain injury: a prospective diagnostic accuracy study

  • by Weidong Wang, Huajun Wang, Chengjie Zhou, Ye Fu

  • June 10, 2026

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