Immunoinformatics-driven design of a multi-epitope vaccine against Clostridium perfringens in yaks - Takeaways - MDSpire

Immunoinformatics-driven design of a multi-epitope vaccine against Clostridium perfringens in yaks

  • By

  • Dan Wu

  • Runbo Luo

  • Kexin Li

  • Yulin Peng

  • Xiao Yue

  • Yurui Wang

  • Haoyu Fan

  • Yifang Wen

  • Yixin Huang

  • Sizhu Suolang

  • Suizhong Cao

  • June 29, 2026

  • 0 min

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  • 1

    Clostridium perfringens causes enterotoxemia in yaks, leading to significant economic losses on the Qinghai-Tibet Plateau.

  • 2

    Conventional vaccines for C. perfringens show limited efficacy and protective breadth, necessitating innovative vaccine strategies.

  • 3

    A novel multi-epitope vaccine was designed using immunoinformatics, incorporating epitopes from toxinotypes A, C, and E.

  • 4

    The vaccine demonstrated high antigenicity, structural stability, and strong binding affinity with immune receptors TLR2 and TLR4.

  • 5

    In silico cloning confirmed the potential for efficient expression of the vaccine in E. coli, paving the way for further validation.

Original Source(s)

Immunoinformatics-driven design of a multi-epitope vaccine against Clostridium perfringens in yaks

  • by Dan Wu, Runbo Luo, Kexin Li, Yulin Peng, Xiao Yue, Yurui Wang, Haoyu Fan, Yifang Wen, Yixin Huang, Sizhu Suolang, Suizhong Cao

  • June 29, 2026

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