Clinicopathological, proliferative, molecular, and prognostic characteristics of differentiated high-grade thyroid carcinoma: a multicenter retrospective study - Takeaways - MDSpire

Clinicopathological, proliferative, molecular, and prognostic characteristics of differentiated high-grade thyroid carcinoma: a multicenter retrospective study

  • By

  • Wenwen Cui

  • Lihang Xing

  • Zhenzhen Li

  • Xinjun Li

  • Junzhi Li

  • July 8, 2026

  • 0 min

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  • 1

    Differentiated high-grade thyroid carcinoma (DHGTC) is a newly defined subtype in the 2022 WHO Classification of Thyroid Tumors.

  • 2

    The study analyzed 19 patients with DHGTC, revealing high invasiveness and a median age of 61 years.

  • 3

    All cases exhibited high-grade features, including increased mitotic activity and a Ki-67 index of ≥10%.

  • 4

    Molecular testing identified BRAF abnormalities in 9 cases, with additional mutations in TERT and p53 in some patients.

  • 5

    During follow-up, 4 patients experienced recurrence or metastasis, and 2 patients died, indicating poor prognosis.

Original Source(s)

Clinicopathological, proliferative, molecular, and prognostic characteristics of differentiated high-grade thyroid carcinoma: a multicenter retrospective study

  • by Wenwen Cui, Lihang Xing, Zhenzhen Li, Xinjun Li, Junzhi Li

  • July 8, 2026

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