Fifteen years of pediatric immune thrombocytopenia in a national cohort: chronicity, diagnostic challenges, and treatment patterns—single center experience

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The study analyzed 271 pediatric patients evaluated for immune thrombocytopenia (ITP) from 2009 to 2024, with 240 diagnosed with ITP.
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Chronic ITP was linked to older age, absence of preceding infections or vaccinations, and higher platelet counts at diagnosis.
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Patients with alternative diagnoses were older and exhibited lower bleeding grades compared to those with ITP.
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Initial treatment decisions for ITP were influenced by clinical presentation, with upfront therapy associated with more severe bleeding complications.
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The findings highlight the need for improved identification of children at risk for chronic ITP and those with alternative causes of thrombocytopenia.

Frontiers In Pediatrics

by Katja Pregeljc, Elena Favaretto, Federico Verzegnassi, Barbara Faganel Kotnik
June 11, 2026

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