Glioma management and outcome in low-middle-income countries: a systematic review

1

Gliomas are the most common primary malignant brain tumors, with low-grade gliomas comprising 62.6% of cases in low- and middle-income countries.
2

The systematic review included 30 studies with 3,463 patients, highlighting significant disparities in glioma management in LMICs.
3

Pooled 5-year overall survival rates were 87.8% for low-grade gliomas and 21.9% for high-grade gliomas, indicating better outcomes for LGGs.
4

Limited access to adjuvant therapies and minimal molecular diagnostic integration characterize glioma management in LMICs.
5

Targeted investments in radiotherapy, chemotherapy access, and molecular diagnostics are essential to improve neuro-oncological care in LMICs.

Frontiers In Oncology

by Adam M. Abdallah, Atef F. Hulliel, Asem A. Almomani, Rawhi Alshaykh, Omar H. Abuhashem, Sara Khaled Aldalki, Tala Y. Dabash, Mohammad Mukahal, Ala’ Marji, Said Mahmoud Lahham, Mouness Obeidat
June 12, 2026

1