Clinical, Radiologic and Cytologic Predictors of Malignancy in Pediatric Thyroid Nodules: Insights From a 26-Year Cohort Study - Takeaways - MDSpire

Predictive Factors for Malignancy in Pediatric Thyroid Nodules: A Comprehensive Analysis from a 26-Year Cohort Study on Clinical, Radiologic, and Cytologic Aspects

  • By

  • Maxime Gest-Laurent

  • Adrien Nguyen Quoc

  • Christine Lefevre

  • Laura González-Briceño

  • Caroline Thalassinos

  • Isabelle Flechtner

  • Dulanjalee Kariyawasam

  • Yamina Dassa

  • Magali Viaud

  • Dinane Samara-Boustani

  • Graziella Pinto

  • Hervé Monpeyssen

  • Sabine Sarnacki

  • Vincent Couloigner

  • Michel Polak

  • Athanasia Stoupa

  • July 6, 2026

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  • 1

    Thyroid nodules in children have a prevalence of 0.2%-5% and a malignancy rate of about 25%, significantly higher than in adults.

  • 2

    Pediatric thyroid cancer is the most common endocrine malignancy, often diagnosed at advanced stages with potential for metastases.

  • 3

    Key risk factors for pediatric thyroid nodules include iodine deficiency, ionizing radiation exposure, and various genetic syndromes.

  • 4

    Ultrasound features indicating higher malignancy risk in pediatric thyroid nodules include solid composition, hypoechogenicity, and irregular margins.

  • 5

    The study aims to identify clinical and ultrasound features associated with malignancy in pediatric thyroid nodules over a 26-year period.

Original Source(s)

Clinical, Radiologic and Cytologic Predictors of Malignancy in Pediatric Thyroid Nodules: Insights From a 26-Year Cohort Study

  • by Maxime Gest-Laurent, Adrien Nguyen Quoc, Christine Lefevre, Laura González-Briceño, Caroline Thalassinos, Isabelle Flechtner, Dulanjalee Kariyawasam, Yamina Dassa, Magali Viaud, Dinane Samara-Boustani, Graziella Pinto, Hervé Monpeyssen, Sabine Sarnacki, Vincent Couloigner, Michel Polak, Athanasia Stoupa

  • July 6, 2026

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