Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT - Takeaways - MDSpire

Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT

  • By

  • Olaf Penack

  • Christophe Peczynski

  • Mohamad Mohty

  • Ibrahim Yakoub-Agha

  • Rafael de la Camara

  • Bertram Glass

  • Rafael F. Duarte

  • Nicolaus Kröger

  • Hélène Schoemans

  • Christian Koenecke

  • Zinaida Peric

  • Grzegorz W. Basak

  • October 30, 2021

  • 0 min

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  • 1

    Allogeneic hematopoietic cell transplantation (allo-HCT) is a growing treatment for hematological malignancies, with nearly 20,000 procedures reported annually in Europe.

  • 2

    The Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI) was adapted to assess comorbidities associated with non-relapse mortality (NRM) in allo-HCT.

  • 3

    The study aimed to evaluate the association of pre-existing comorbidities with NRM after allo-HCT, hypothesizing a lower association compared to earlier HCT-CI populations.

  • 4

    Data for the analysis was collected from the EBMT registry, including patient characteristics, transplant details, and comorbidity assessments from 2010 to 2018.

  • 5

    The primary endpoint of the study was NRM, with secondary endpoints including overall survival, progression-free survival, and incidence of graft-versus-host disease.

Original Source(s)

Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT

  • by Olaf Penack, Christophe Peczynski, Mohamad Mohty, Ibrahim Yakoub-Agha, Rafael de la Camara, Bertram Glass, Rafael F. Duarte, Nicolaus Kröger, Hélène Schoemans, Christian Koenecke, Zinaida Peric, Grzegorz W. Basak

  • October 30, 2021

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