Molecular Profiling, Prognostic Insights, and Immune Landscape Evaluation of NUDT16 in Clear Cell Renal Cell Carcinoma - Takeaways - MDSpire

Molecular Profiling, Prognostic Insights, and Immune Landscape Evaluation of NUDT16 in Clear Cell Renal Cell Carcinoma

  • By

  • Chen Chen

  • Zhuojing Hu

  • Wei Zhao

  • Yunbo Ma

  • Qinghua Xia

  • November 21, 2025

  • 0 min

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  • 1

    Clear cell renal cell carcinoma (ccRCC) accounts for 70-80% of renal cell carcinoma cases, with poor prognosis in advanced stages.

  • 2

    NUDT16 is a decapping enzyme that plays a critical role in mRNA degradation and has implications in DNA damage repair.

  • 3

    This study utilized RNA-seq data to analyze NUDT16 expression and its prognostic significance in ccRCC compared to normal tissues.

  • 4

    Multivariate Cox regression and nomograms were developed to assess the prognostic outcomes associated with NUDT16 expression.

  • 5

    The research highlights NUDT16's potential as a therapeutic target and its role in immune cell infiltration in ccRCC.

Original Source(s)

Molecular Profiling, Prognostic Insights, and Immune Landscape Evaluation of NUDT16 in Clear Cell Renal Cell Carcinoma

  • by Chen Chen, Zhuojing Hu, Wei Zhao, Yunbo Ma, Qinghua Xia

  • November 21, 2025

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