Octenidine or Sterile Water Cleansing and Late-Onset Sepsis in Neonates in the NICU: A Randomized Clinical - Takeaways - MDSpire

Octenidine or Sterile Water Cleansing and Late-Onset Sepsis in Neonates in the NICU: A Randomized Clinical

  • By

  • Shreya Udavant

  • Suprabha Patnaik

  • Sanjay Lalwani

  • Pradeep Suryawanshi

  • Rupeshkumar Deshmukh

  • July 15, 2026

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  • 1

    Late-onset sepsis (LOS) affects 0.6% to 14.2% of neonates in NICUs, with higher incidence in low- and middle-income countries.

  • 2

    Octenidine dihydrochloride has faster bactericidal activity and longer residual effects compared to chlorhexidine.

  • 3

    This randomized clinical trial compares daily octenidine cleansing to sterile water cleansing for preventing LOS in NICU neonates.

  • 4

    Eligible neonates were randomly assigned to receive either octenidine wipes or sterile water for daily cleansing.

  • 5

    The study protocol was approved by the institutional ethics committee and followed good clinical practice guidelines.

Original Source(s)

Octenidine or Sterile Water Cleansing and Late-Onset Sepsis in Neonates in the NICU: A Randomized Clinical

  • by Shreya Udavant, Suprabha Patnaik, Sanjay Lalwani, Pradeep Suryawanshi, Rupeshkumar Deshmukh

  • July 15, 2026

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