Case Study: Non-secretory Multiple Myeloma with Eosinophilia - Diagnostic Hurdles and a Comprehensive Literature Review - Takeaways - MDSpire

Case Study: Non-secretory Multiple Myeloma with Eosinophilia - Diagnostic Hurdles and a Comprehensive Literature Review

  • By

  • Jirui Zhong

  • Xikun Liu

  • Jiduo Liu

  • Shanshan Xiao

  • Xuekui Gu

  • Zenghui Liu

  • April 22, 2026

  • 0 min

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  • 1

    A 56-year-old man with non-secretory multiple myeloma presented with marked eosinophilia and significant diagnostic challenges.

  • 2

    Laboratory tests revealed persistent eosinophilia, thrombocytopenia, elevated LDH, and imaging showed multifocal osteolytic lesions.

  • 3

    Negative results from serum and urine immunofixation electrophoresis complicated the diagnosis of non-secretory multiple myeloma.

  • 4

    Bone marrow analysis confirmed plasma-cell neoplasm, with cytogenetic testing revealing abnormalities including RB1 deletion.

  • 5

    This case emphasizes the need for comprehensive evaluation in atypical presentations of multiple myeloma, especially with eosinophilia.

Original Source(s)

Case Study: Non-secretory Multiple Myeloma with Eosinophilia - Diagnostic Hurdles and a Comprehensive Literature Review

  • by Jirui Zhong, Xikun Liu, Jiduo Liu, Shanshan Xiao, Xuekui Gu, Zenghui Liu

  • April 22, 2026

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