Casein hydrolysate promotes intestinal repair in adult mice with Salmonella enteritis through a lactate-GPR81-Wnt3A axis in intestinal stem cell niche - Takeaways - MDSpire

Casein hydrolysate promotes intestinal repair in adult mice with Salmonella enteritis through a lactate-GPR81-Wnt3A axis in intestinal stem cell niche

  • By

  • Jianbo Cheng

  • Jing Li

  • Yuying Bai

  • Shi Wang

  • Lirui Sun

  • June 15, 2026

  • 0 min

Share

  • 1

    Casein enzymatic hydrolysate (CEH) improves survival and reduces disease severity in mice infected with Salmonella enterica serovar Typhimurium.

  • 2

    CEH administration restores intestinal barrier function and promotes intestinal stem cell regeneration in the context of Salmonella-induced enteritis.

  • 3

    CEH reshapes gut microbiota, increases lactate-producing genera, and elevates luminal L-lactate levels, enhancing intestinal healing.

  • 4

    Lactate supplementation enhances CEH's protective effects on Paneth cell function and inflammatory responses in the intestinal microenvironment.

  • 5

    CEH's protective mechanism involves the lactate-GPR81-Wnt3A axis, which is crucial for intestinal stem cell activity and mucosal repair.

Original Source(s)

Casein hydrolysate promotes intestinal repair in adult mice with Salmonella enteritis through a lactate-GPR81-Wnt3A axis in intestinal stem cell niche

  • by Jianbo Cheng, Jing Li, Yuying Bai, Shi Wang, Lirui Sun

  • June 15, 2026

Related Content

Gut microbial bile salt hydrolase as a metabolic gatekeeper in digestive homeostasis and disease

3 Innovations Revolutionizing IBD Treatment

Keck Medicine of USC gastroenterologist Florence-Damilola (Damie) Odufalu, MD, shares how recent advances in inflammatory bowel disease treatment are changing the lives of patients.

  • by

  • May 26, 2026

  • 5 min
Fecal microbiota transplantation reduces inflammation and modulates gene expression in HIV-infected double humanized-BLT (dHu-BLT) mice on antiretroviral therapy