Tea saponin–soybean oil submicron emulsion promotes durable protective immunity against Pasteurella multocida - Takeaways - MDSpire

Submicron Emulsion of Tea Saponin and Soybean Oil Enhances Long-lasting Immune Protection Against Pasteurella multocida

  • By

  • Xuemei Cui

  • Le Yu

  • Ruiting Zhang

  • Yee Huang

  • Zizhe Hu

  • Xiaoyu Li

  • Quanan Ji

  • Tuanyuan Shi

  • Guolian Bao

  • Yan Liu

  • July 20, 2026

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  • 1

    The study developed a tea saponin-soybean oil submicron emulsion (TS-Pm) to enhance immune responses against inactivated Pasteurella multocida.

  • 2

    TS-Pm formed a stable emulsion with a particle size of approximately 300 nm and demonstrated preserved morphology after 6 months at 4 °C.

  • 3

    In vitro, TS-Pm increased macrophage antigen uptake and pro-inflammatory cytokine production compared to traditional alum-adjuvanted vaccines.

  • 4

    In vivo, TS-Pm improved survival rates to 90% after lethal challenge, outperforming the 60% survival rate of the alum-adjuvanted vaccine.

  • 5

    Draining lymph-node proteomics revealed immune program changes associated with TS-Pm, including antigen processing and NF-κB-related signaling.

Original Source(s)

Tea saponin–soybean oil submicron emulsion promotes durable protective immunity against Pasteurella multocida

  • by Xuemei Cui, Le Yu, Ruiting Zhang, Yee Huang, Zizhe Hu, Xiaoyu Li, Quanan Ji, Tuanyuan Shi, Guolian Bao, Yan Liu

  • July 20, 2026

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