Survival benefit of extended lymphadenectomy in endometrial cancer: a meta-analysis with risk-stratified subgroup analysis - Takeaways - MDSpire

Survival benefit of extended lymphadenectomy in endometrial cancer: a meta-analysis with risk-stratified subgroup analysis

  • By

  • Yunlong Fan

  • Jun Zhu

  • Lingling Jiang

  • Jia Xu

  • Jinqun Huang

  • June 10, 2026

  • 0 min

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  • 1

    The meta-analysis evaluated the impact of combined pelvic and para-aortic lymphadenectomy on overall survival in endometrial cancer patients.

  • 2

    Fourteen studies involving 25,432 patients were included, with a focus on comparing PPaLND, PLND, and no lymphadenectomy.

  • 3

    PPaLND showed a significant improvement in overall survival compared to no lymphadenectomy, with a hazard ratio of 0.61.

  • 4

    No significant survival differences were found between PPaLND and PLND in intermediate-to-high-risk subgroups, indicating low statistical power.

  • 5

    The study highlights the need for prospective trials to validate the optimal surgical strategy for endometrial cancer.

Original Source(s)

Survival benefit of extended lymphadenectomy in endometrial cancer: a meta-analysis with risk-stratified subgroup analysis

  • by Yunlong Fan, Jun Zhu, Lingling Jiang, Jia Xu, Jinqun Huang

  • June 10, 2026

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