Targeting Liver Metastases in Uveal Melanoma: ATX-LPA Mediated Immunosuppression and Novel Therapeutic Approaches

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Uveal melanoma shows a strong tendency to metastasize to the liver, where immune tolerance aids in disease progression.
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Impaired CD8+ T cell immunosurveillance is a key factor in the progression of uveal melanoma.
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The ATX-LPA axis is identified as a significant immunoregulatory pathway in the liver tumor microenvironment.
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CD8+ T cells from hepatic metastasis exhibit significantly higher ATX transcripts compared to peripheral blood and healthy controls.
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Genetic deletion of the LPA5 receptor on CD8+ T cells enhances their function during persistent antigen stimulation in the presence of LPA.

Frontiers In Immunology

by A. Turner, Jacqueline , D'Antonio, Marc , Montane, Heather , MacBeth, Morgan , Katsnelson, Elizabeth , Robinson, William , Tobin, Richard , Couts, Kasey L., Markovic, Svetomir N, Torres, Raul M
May 29, 2026

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