Prognostic value of existing scoring systems for early mortality in phase I immunotherapy trials: a head-to-head real-world cohort study - Takeaways - MDSpire

Evaluating the Prognostic Utility of Established Scoring Systems for Early Mortality in Phase I Immunotherapy Trials: A Comparative Real-World Cohort Analysis

  • By

  • Paloma Sangro

  • Ana Landa-Magdalena

  • Miguel Sogbe

  • Teresa Zumarraga

  • Ignacio Matos

  • Mariano Ponz-Sarvise

  • Marina Crespo

  • María Esperanza Rodriguez-Ruiz

  • Anna Vilalta-Lacarra

  • Eduardo Castañón

  • July 20, 2026

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  • 1

    The study analyzed 844 patients in phase I immunotherapy trials to compare the prognostic performance of five established scoring systems.

  • 2

    All five prognostic scores demonstrated statistically significant prognostic stratification, with C-index values ranging from 0.55 to 0.69.

  • 3

    The ROPRO score had the highest 3-month AUC of 0.76, indicating better predictive performance compared to the other scores.

  • 4

    No scoring system identified a subgroup of patients with a median overall survival below the 3-month threshold.

  • 5

    The findings suggest that while scores stratify prognosis, they should not be used as rigid exclusion criteria in patient selection.

Original Source(s)

Prognostic value of existing scoring systems for early mortality in phase I immunotherapy trials: a head-to-head real-world cohort study

  • by Paloma Sangro, Ana Landa-Magdalena, Miguel Sogbe, Teresa Zumarraga, Ignacio Matos, Mariano Ponz-Sarvise, Marina Crespo, María Esperanza Rodriguez-Ruiz, Anna Vilalta-Lacarra, Eduardo Castañón

  • July 20, 2026

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